Pharmaceutical Sciences
Year: 2024
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H. Leuenberger, The Organic Supercomputer, able to Replicate as Virtual Patient, Proceedings 2023 SIPS Summit, Hyatt Playa Bonita, Panama City, Vol.11, sips23_65_63FS, Intern. Symp. on Technological Innovations in Medicine, edited by F. Kongoli, F. Murad, T. Yoshikawa, J.R. Ribas, D. Joseph, N. Tran, S. Hirano FLOGEN 2023.
Year: 2023
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H. Leuenberger, The Organic Supercomputer, able to Replicate as Virtual Patient, SIPS Summit, November 27- December 1, 2023, at Hyatt Playa Bonita, Panama City, ppt presentation, pdf version can be downloaded from https://www.ifiip.ch.
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S. Schmidt, S. Kim, V. Vozmediano, R. Cristofoletti, Z. Lin, N. de Moraes, F. Azeredo, B. Cicali, H. Leuenberger, J. D. Brown, J. Y. Jin, C. J. Musante, S. Tannenbaum, Y. Wan, Requirements, expectations, challenges, and opportunities associated with training the next generation of pharmacometricians, CPT Pharmacometrics Syst Pharm. Vol. 12 (2023): 883–88.
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H. Leuenberger, Keynote Lecture, Impact of the Digital Revolution on the Future of Formulation Science, Gala Technology event, 10th BIT Annual World Congress on Nano Science & Technology at Hyatt Regency Hotel, Osaka, May 17-20, 2023.
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H. Leuenberger, Spray Freeze Drying and New Research Avenues, invited lecture by Dr. Go Kimura, Senior Director, Formulation Department, CMC Research Innovation Office, SHIONOGI, Hyogo, JAPAN, May 15, 2023.
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H. Leuenberger, Spray Freeze Drying and the Future of Pharmaceutical Technology, invited lecture by POWREX, Shonan-I-Park, near Kamakura City, Japan, May 12, 2023.
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H. Leuenberger, Keynote Lecture, Artificial Intelligence AI, Digital Revolution in Formulation Science & New Avenues in Drug Discovery, IDDST Gala Technology Cluster event, Tokyo, May 8 - 10, 2023.
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H. Leuenberger, Opening Celebration address at the Gala Technology Cluster event, Shinagawa Prince Hotel, Tokyo, May 8, 2023.
Year: 2021
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H. Leuenberger, Business Ethics in the Pharmaceutical Industry and Beyond. In SWISS PHARMA, 2021, Volume 43, p. 19-29.
- H. Leuenberger, Debate: Nanoparticles – A Blessing or a Curse, Chapter in the book Ethics and Nanotechnology, editors Van De Voorde M, Jeswani G. [Ethics in Nanotechnology (degruyter.com)].
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H. Leuenberger, Spray Freeze-Drying for Formulations of Precision Medicine and Vaccines, SWISS PHARMA, Vol. 43, 4, (2021):10-18.
Year: 2019
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H. Leuenberger, What is Life, A new Human Model of Life, Disease and Death – a Challenge for Artificial Intelligence and Bioelectric Medicine Specialists, SWISS PHARMA, 41. 1, (2019): 20- 36.
Year: 2018
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H. Leuenberger, S. K. El-Arini and G. Betz. Book chapter Pharmaceutical Powder Technology –ICH Q-8 and building the pyramid of Knowledge, book chapter in Water-Insoluble Drug Form. (2018). 3rd Edition, Editor: Liu, Rong. Publisher: Interpharm Press.p.568-587.. [Digital version]
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Thanks to Dr Liu and the Bostal Group the 3rd edition of the book Water-Insoluble Drug Formulation is also available in Chinese published by Chemical Industry Press (ISBN 978-7-122-39372-2
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K. Saeting, G. Kimura, A. Mitrevej, N. Sinchaipanid and H. Leuenberger. A systematic pharmaceutical technology drug-excipient screening program for pre-formulation studies, SWISS PHARM, Vol, 34, (2018):.61-66.
Year: 2017
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D. Maneerojpakdee, A. Mitrevej, N. Sinchaipanid, J. Nowak and H. Leuenberger. An Attempt to Adopt the Workflow of the Automotive and Aircraft Industry for the Design of Drug Delivery Vehicles, invit[Digital version]ed publication, PHARM TECH JAPAN Vol. 33, (2017): 145- 156 (Article published in English as well as in Japanese).
Year: 2016
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H. Leuenberger, M. N. Leuenberger, Impact of the Digital Revolution on the Future of Formulation Science, invited publication, European Journal of Pharm. Sci. Vol., 87, (2016): 100-111. The above paper (invited paper) is republished in English & in Japanese in Pharm. Tech. Japan 33, 2017: 33-38; p. 55-64.
Year: 2014
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H. Leuenberger, Ceremonial Address, 10th Anniversary of the Galenus Privatstiftung in Vienna, can be downloaded from
https://www.ifiip.ch, Festvortrag.
Year: 2013
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H. Leuenberger, G. Kimura, Basic Principle and New Development of Percolation Theory for Pharmaceutical Development, PHARM TECH JAPAN, Vol.29, 14, (2013): 91-93, 2nd part.
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H. Leuenberger, M. Puchkov, B. Schneider, Right First Time Concept and Workflow, SWISS PHARMA Vol. 35 (2013): 3 -16.
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H. Leuenberger, M. Puchkov, B. Schneider, G. Kimura, Right First Time Concept and Workflow, PHARM TECH JAPAN, Vol. 29, 12, (2013): 41-52, 1st part.
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H. Leuenberger, M. Puchkov, B. Schneider,G. Kimura. Right First Time Concept and Workflow, PHARM TECH JAPAN, Vol. 29, 13, (2013): 45-55, 2nd part.
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H. Leuenberger, M. Puchkov, B. Schneider, Right First Time Concept and Workflow, SWISS PHARMA Vol. 35 (2013): 3 -16.
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H. Leuenberger et al. Roundtable Discussion of the eve of the 5th Pharmaceutical Technology Conference Tokyo November 2013 published in PHARM TECH JAPAN 14/2 (see https://www.ifiip.ch, downloads PHARM TECH JAPAN).
Year: 2012
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H. Leuenberger, G. Kimura, Basic Principle and New Development of Percolation Theory for Pharmaceutical Development, PHARM TECH JAPAN, Vol.28, 14, (2012): 107-111, 1st part.
Year: 2011
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M. Puchkov and H. Leuenberger, Computer-Aided Design of Pharmaceutical Formulations, F-CAD software and Mathematical Concept, Glatt International Times, Vol.31, (2011): 2 – 6.
Year: 2010
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S. Sehic, G. Betz, S. Hadzidedic, S. K. El-Arini and H. Leuenberger. Investigation of intrinsic dissolution behavior of different carbamazepine samples, Int. J. Pharm. Vol. 386,1-2), (2010): 77-90.
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E. Hadzovic, G. Betz, S. Hadzidedic, S. K. El-Arini and H. Leuenberger. Roller compaction of different pseudopolymorphic forms of Theophylline: Effect on compressibility and tablet propertieS, Int. J. Pharm. Vol.396, 1-2, (2010): 53-62.
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H. Leuenberger, M. N. Leuenberger and Puchkov, Right First Time, Computer-Aided Scale-up
for manufacturing solid dosage forms with a shorter time to market, SWISS PHARMA, Vol. 32, 7-8, (2010): 3-13.
Year: 2009
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V. Balzano. Soft tabletting of MCC 102 and UICEL-A/102 pellets into multiple unit pellet systems., PhD thesis, 2009.
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E. Krausbauer. Contributions to a science based expert system for solid dosage form design, PhD thesis, 2009.
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M. Rumman, Understanding the functionality of MCC Rapid as an excipient for DC - Moving towards QbD, PhD thesis, 2009.
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H. Leuenberger, M. N. Leuenberger2 and M. Puchkov, Implementing Virtual R&D reality in industry: In-silico design and testing of solid dosage forms, SWISS PHARMA, Vol. 31, 7-8, (2009): 18-24.
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L. Maurer and H. Leuenberger Terahertz pulsed imaging and near infrared imaging to monitor the coating process of pharmaceutical tablets, Int. J. Pharm. Vol. 370, 1-2, (2009): 8-16.
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H. Leuenberger, M. Puchkov, E. Krausbauer and G. Betz. Manufacturing pharmaceutical granules: Is the granulation endpoint a myth? Powder Tech., Vol. 189, (2009): 141-148.
Year: 2008
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U. J. Bausch, Impact of filling processes on protein solutions, PhD thesis, 2008
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T. A. Meyer, Novel determination of powder mixing qualities and study of dry coated particles, PhD thesis, 2008
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E. Hadzovic, Roller compaction of theophylline, PhD thesis, 2008
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F. S. Mueller. Modified celluloses as multifunctional excipients in rapidly dissolving immediate release tablets, PhD thesis, 2008
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L. Maurer. Near infrared spectroscopy/imaging and terahertz pulsed spectroscopy/imaging for the analysis of solid dosage forms, PhD thesis, 2008
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K. Oppel, Taste masking of an active pharmaceutical ingredient for veterinary application, PhD theis, 2008,
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M. Pasic. Study to design stable lansoprazole pellets. PhD thesis, 2008
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S. Sehic, Investigation of variability of primary materials on the intrinsic dissolution behavior of carbamazepine, PhD thesis, 2008,
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A. M. Guntermann. Untersuchung der Tablettiersimulation mit dem PressterTM in Abhängigkeit von der Formulierung, Chargengrösse und der Tablettenpresse, PhD thesis, 2008
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Y. Y. Pittini, D. Daneshvari, R. Pittini, S. Vaucher. L. Rohr, S. Leparoux, Hans Leuenberger, Cole–Cole plot analysis of dielectric behavior of monoalkylethers of polyethyleneglycol (Cn Em), European Polymer J., Vol.44, 4, (2008): 1191-1199.
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H. Leuenberger & F. Wuest, Editorial, The Swiss Society of Pharmaceutical Sciences (SSPhS) and the journal SWISS PHARMA agree upon a close collaboration. The objective is to promote cooperation between the Swiss academic institutions and the pharmaceutical industry, SWISS PHARMA, Vol. 30, 9, (2008): 5.
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H. Leuenberger, Swiss Society of Pharmaceutical Sciences (SSPhS) and Swiss Academy of Pharmaceutical Sciences (SAPhS). The promotion of the scientific interests of the Swiss pharmacy sector, SWISS PHARMA, Vol. 30, 9, (2008): 6-8.
Year: 2007
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M. S. Faatz. Ländervergleich Irland-Schweiz betreffend der bildungspolitischen Rahmenbedingungen für die globale pharmazeutische Industrie,.PhD thesis, 2007
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D. Daneshvari. Investigation of binary polar solvent mixtures, solubilized ferroelectric salts and paraffin-based derivatives using dielectric spectroscopy, PhD thesis, 2007
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G. Kimura, G. Betz, H. Leuenberger, Influence of loading amount of mefenamic acid on granulation and tablet characteristic using compaction simulator, Pharm. Dev. Techn. Vol.12, (2007): 627-635.
Year: 2006
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H. Valpórsson, PAT implementation in pharmaceutical manufacturing and its economical impact, PhD thesis. 2006
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L. R. Farfan, Ganzheitliche systemische Qualitätsbetrachtung in der Produktion fester Arzneiformen ein praxisorientiertes Vorgehensmodell anhand einer Synthese der Methoden Prozesssimulation und multivariate Datenanalyse,PhD thesis, 2006
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M. Walter. Integration und Evaluation neuer Medien angewandt in der Lehre der pharmazeutischen Technologie an der Universität Basel, Erfahrungen bei der Entwicklung und Umsetzung, PhD thesis, 2006
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H. Nalenz, Dependence of skin drug permeation on microstructure and time dependent alterations following application of more-phasic dermatological formulations studied by the continuous phase drug concentration concept, PhD thesis, 2006
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C. A. Sautter, Sustained release injectables formed "in-situ" for veterinary use, PhD thesis, 2006. [Digital version] P
M. Plitzko, Gefriertrocknung in der Wirbelschicht : Möglichkeiten und Grenzen fuer die Anwendung in der Pharmazie, PhD thesis, 2006. -
M. Lanz., Pharmaceutical powder technology towards a science based understanding of the behavior of powder systems, PhD thesis, 2006.
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H. Leuenberger. Pharmaceutical Technology: Drug Delivery, Formulation and Process Research, Chimia, Vol. 60, (2006):40-45.
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H. Leuenberger, From Functional Excipients to Drug Carrier Systems, Chemistry Today, Vol. 24, 5, (2006): 64-66.
- Annual Report 2006, Institute of Pharmaceutical Technology, University of Basel, (pdf)
Year: 2005
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M. P. Altenbach. Cutaneous metabolism, tissue binding, lipophilicity and electroosmosis : relevance for iontophoretic enhancement, PhD thesis 2005.
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B. Egger-Heigold. The effect of excipients on pharmacokinetic parameters of parenteral drugs, PhD thesis 2005
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J. C. von Orelli, Search for technological reasons to develop a capsule or a tablet formulation, PhD thesis, 2005
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S. Reitbauer. Einfluss pharmazeutischer Hilfsstoffe auf die Plamasmembran von Caco-2 Zellmonolayern ermittelt durch Fluoreszenzdepolarisation, PhD thesis. 2005
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A. U. Schiffmann. Modellierung und Formulierung von WIP (Washing In Place) - und CIP (Cleaning In Place) - Konzepten fuer Wirbelschichtanlagen PhD thesis, 2005
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G. Betz, A. Aeppli, N. Menshutina and H. Leuenberger. In vivo comparison of various liposome formulations for cosmetic application, Int. J. Pharm. Vol. 296, (2005): 44-54.
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H. Leuenberger and M. Lanz. Pharmaceutical powder technology -- from art to science: the challenge of the FDA's Process Analytical Technology Initiative, Advanced Powder Technology, Vol.16, 1, (2005): 3-25.
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G. Hernandez-Perni, A. Stengele and H. Leuenberger. Towards a better understanding of the parameter Ei/E in the characterization of polar liquids, Intern. J. of Pharm. Vol. 291 (2005): 189–195.
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G. Hernandez-Perni, A. Stengele and H. Leuenberger, Detection of percolation phenomena in binary polar liquids by broadband dielectric spectroscopy, Intern. Journal of Pharm. Vol. 291 (2005): 197–209.
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G. Hernandez-Perni and H. Leuenberger. The characterization of aprotic polar liquids and percolation phenomena in DMSO/water mixtures, European Journal of Pharmaceutics and Biopharmaceutics Vol. 61, (2005): 201–213.
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H. Leuenberger, G. Betz, D. Jones, book chapter, Scale-up in the field of Granulation and Drying in Scale-up of Pharmaceutical Processes, editor M. Levin, 2005,
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K. Iida, Y. Hayakawa, H. Okamoto, T. Hiroaki, O. Hirokazu, K. Danjo, H. Leuenberger Influence of storage humidity on the in vitro inhalation properties of salbutamol sulfate dry powder with surface covered lactose carrier, PHARM TECH JAPAN, Vol.21, 5, (2005): 743-748.
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N. V. Menshutina, A. E. Korneeva, H. Leuenberger, Modeling of Atmospheric Freeze Drying in a Spouted Bed, TFCEAU (Theoretical Foundations of Chemical Engineering) Vol. 39, 6, (2005): 5.94-598.
- Annual Report 2005, Institute of Pharmaceutical Technology, University of Basel, (pdf)
Year: 2004
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T. T. Kuny. Compression behavior of the enzyme ß-galactosidase PhD thesis, 2004.
M. E. Perni. "A contribution to the understanding of percolation phenomena in binary liquids, PhD thesis, 2004. -
C. Gräflein. Parenterale Ernährung mit stabilitätsgeprueften, modularen Standardnährlösungen in der Neonatologie, phD thesis, 2004.
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Y. Fukumori, H. Leuenberger and M. Horio, Preface for Special Issue on Pharmaceutical Particle Formation, Powder Technol. Vol. 141 (3), (2004): 171-171.
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A. Schiffmann, J. A. Dressler, B. Luy, H. Leuenberger, Effects on the Quality of Granules Obtained in Conventionally Designed Fluid-bed Equipment Compared to Granules Obtained in a Washing In Place/Cleaning In Place Designed Unit, Pharm.Ind. Vol. 66 (8), (2004): 1024-1030.
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J. von Orelli and H. Leuenberger. Search for technological reasons to develop a capsule or a tablet formulation with respect to wettability and dissolution, Intern. J. of Pharm. Vol. 287 (2004): 135–145.
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G. Betz, P. J. Bürgin and H. Leuenberger. Power consumption measurement and temperature recording during granulation, Int. J. Pharm. Vol. 272, (2004): 137-149.
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J. Werani, M. Grünberg, C. Ober and H. Leuenberger. Semicontinuous granulation - the process of choice for the production of pharmaceutical granules? Powder Technol. Vol. 140 (3), (2004): 163-168.
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M. Reus-Medina, M. Lanz,V. Kumar and H .Leuenberger, Comparative evaluation of the powder properties and compression behavior of a new cellulose-based direct compression excipient and Avicel PH-102, J. of Pharmacy and Pharmacology, J. of Pharmacy and Pharmacology, Vol. 56, (2004): 951-956.
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G. Betz, A. Meyer, M. Puchkov, H. Leuenberger, Investigation of granulation and comparison of tablet compaction properties of polymorphs of Mannitol after wet granulation with direct compressible Mannitol using a compaction simulator, Proceedings International Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology; Nurnberg, March 15-18, 2004, p. 101-102.
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H. Trobradovic, G. Betz, S. Kocova, S. Hadžidedić, H. Leuenberger, Differential scanning calorimetry as a tool for the prediction of the compatibility and stability of multicomponent drug systems, Proceedings International Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology; Nurnberg, March 15-18, 2004, p.161-162.
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N.V. Menshutina, A.E. Korneeva. S. V. Goncharova, H. Leuenberger,
Atmospheric Spray Freeze Drying with fluidized bed of Mannitol. Proceedings International Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology; Nurnberg, March 15-18, 2004, p.303-304. -
H. Leuenberger, M. Plitzko, M. Puchkov, Modelling of the spray-freeze drying process,
Proceedings International Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology; Nurnberg, March 15-18, 2004, p. 871-872. -
K. Iida, Y. Hayakawa, H. Okamoto, K. Danjo, H. Leuenberger, Effect of Surface Layering Time of Lactose Carrier Particles on Dry Powder Inhalation Properties of
Salbutamol Sulfate, Chem. Pharm. Bull. Vol. 52 (3), (2004): 350-353. -
K. Iida, Y. Hayakawa, H. Okamoto, K. Danjo, H. Leuenberger, Influence of Storage Humidity on the in Vitro Inhalation Properties of Salbutamol Sulfate Dry Powder with Surface Covered Lactose Carrier, Chem. Pharm. Bull. Vol. 52 (4), (2004): 444-446.
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N.V. Menshutina, H. Leuenberger, S.V. Goncharova, D.V. Shishulin, Е.О. Lebedev, A.E. Korneeva, Multimedia education courses for chemical technology and pharmaceutics. Textbook in Russian, 2004, MUCTR, 132 pp.
- Annual Report 2004, Institute of Pharmaceutical Technology, University of Basel, (pdf)
Year: 2003
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L. Sukowski. NIR based process analytical technology: in-line residual moisture determination for a complete batch inspection of lyophilized end-products, PhD thesis, 2003.
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G. Betz, P. J. Bürgin and H. Leuenberger. Power consumption profile analysis and tensile strength measurements during moist agglomeration, 2003. Int. J. Pharm. Vol. 252 (1.2), (2003): 11-25.
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G. Betz, P. J. Bürgin and H. Leuenberger, Batch and Continuous Processing in the Production of Pharmaceutical Granules, Pharm. Dev. Technol. Vol. 8 (3), (2003): 289-297.
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T. Kuny and H. Leuenberger. Compression behavior of the enzyme [beta]-galactosidase and its mixture with microcrystalline cellulose, Int. J .Pharm. Vol. 260 (1), (2003): 137-147.
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C. Reinke, J. Breitkreutz, H. Leuenberger, Aluminium in over the-counter-drugs: Risks outweigh benefits? Drug Safety Vol. 26 (14), (2003): 1011-1025.
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K. Iida, Y. Hayakawa, H. Okamoto, K. Danjo, H. Leuenberger Hans, Effect of Surface Covering of Lactose Carrier Particles on Dry Powder Inhalation Properties of Salbutamol Sulfate, Chem. Pharm. Bull. Vol. 51 (12) (2003): 1455-1457.
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K. Iida, Y. Hayakawa, H. Okamoto, K. Danjo, H. Leuenberger, Evaluation of Flow properties of Dry Powder Inhalation of Salbutamol Sulfate with Lactose Carrier, PHARM TECH JAPAN, Vol. 19, 3, (2003):39[359]-46[366].
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A.E. Korneeva, M.N. Puchkov, A.A.Voynovskiy, N.V. Menshutina, H. Leuenberger. Modeling of freeze drying process in fluidized bed spray dryer, Izvestiya Vuzov (in Russian), 2003.
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T. Kuny, C. Schatz, M. Ulmschneider, S. Marrer, H. Leuenberger,
Non-destructive Dissolution Testing Correlation. Distech Vol. 10 (1), (2003): 22-28. -
G. Betz, P. J. Bürgin and H. Leuenberger, Power consumption profile analysis and tensile strength measurements during moist agglomeration, Int. J. Pharm. Int.J.Pharm., Vol. 252 (1.2),
(2003): 11-25. -
K. Iida, Y. Hayakawa, H. Okamoto, K. Danjo, H. Leuenberger, Preparation of Dry Powder Inhalation by Surface Treatment of Lactose Carrier Particles, Chem.Pharm.Bull. 51 (1), 2003, 1-5.
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H. Leuenberger, Research Activities at the Institute or Pharmaceutical Technology of the University of Basel, Proceedings, Albi International Rencontres in Pharmaceutical Engineering, Ecole des Mines Albi-Carmaux; Albi, France, Oct 11.2001, Editors: M. Baron, J. Dodds, ISBN 2-9511591-2-9.
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H. Leuenberger, Scale-up in the 4th dimension in the field of granulation and drying or how to avoid classical scale-up, Powder Technol. Vol.130 (1.3), (2003): 225-230.
- Annual Report 2003, Institute of Pharmaceutical Technology, University of Basel, (pdf)
Year: 2002
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A. Stengele, S. Rey and H. Leuenberger. A novel approach to the characterization of polar liquids. Part 2: binary mixtures, 2002.
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A. Stengele, S. Rey, H. Leuenberger, A novel approach to the characterization of polar liquids Part 2: Hydrophilic Solutions, Int. J .Pharm. Vol.241 (2), (2002): 231-240.
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D.V. Shishulin D.V., N.V. Menshutina., G.A. Avramenko, H. Leuenberger, L.S. Gordeev,
Creation of multimedia education courses in the pharmaceutics area. Proceedings CHISA
15th International Congress of Chemical and Process Engineering, Prague , August 25-29, 2002. -
J. Werani, M. Grunberg, C. Ober, H. Leuenberger, From Batch to Continuous Processes. A new trend in the Production of pharmaceutical granulates, Proceedings 4th World Congress on Particle Technology; Sydney, Australia, July 21-25, 2002. ISBN 085 825 7947.
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H. Leuenberger, Nanocomposite drug carriers for low water soluble drugs. Proceeding PARTICLES 2002, Orlando, April 20-23, 2002, p. 99.
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Martin, Physikalische Pharmazie, book, in German, 4th Edition 2002. Editor: Leuenberger Hans, ISBN 3-8047-1722-5.
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H. Leuenberger, Powder - the fourth state of matter? Pharm. Technol. Japan, Vol.18 ,7, (2002}: 995-1001.
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H. Leuenberger, Spray Freeze Drying - The Process of Choice for low water-soluble Drugs? J. Nanoparticle Res. Vol. 4,1.2, (2002): 111-119.
- Annual Report 2002, Institute of Pharmaceutical Technology, University of Basel, (pdf)
Year: 2001
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H. Leuenberger, Geist und Geld, Fuer einen gemeinsamen Aufbruch in Lehre und Forschung, NZZ vom 24.7.2001, p.12 P
A. Stengele, S. Rey, and H. Leuenberger, A novel approach to the characterization of polar liquids: Part 1: pure liquids, Int. J. Pharm. Vol. 225 (1.2), (2001): 123-134. -
H. Leuenberger, Atmospheric Spray Freeze Drying - The Process of Choice for low water- soluble Drugs? Proceedings International Scientific Seminar; Moscow , Sept 10-11, 2001, Moscow, Editors: MenshutinaN.V., Goncharova S.V., Shishulin D.V, ISBN 5-7237-0302-1.
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K. Iida, Y. Hayakawa, H. Okamoto, K. Danjo, H. Leuenberger,:Evaluation of flow properties of dry powder inhalation of salbutamol sulfate with lactose carrier, Chem.Pharm.Bull Vol. 49, 10, (2001): 1326-1330.
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Hans Leuenberger, How to Avoid Scale-up Problems in Manufacturing Pharmaceutical Granules: The Glatt Multicell Concept, PHARM TECH JAPAN Vol.17 (10), (2001): 1563-1569.
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H. Leuenberger, New trends in the production of pharmaceutical granules: batch versus continuous processing, Eur. J. Pharm. Biopharm., Vol. 52 (3), (2001): 289-296.
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H. Leuenberger, New trends in the production of pharmaceutical granules: the classical batch concept and the problem of scale-up, Eur. J .Pharm. Biopharm. 52 (3), 2001, 279-288.
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H. Leuenberger, Powder - the Fourth State of Matter ?, Proceedings 18th Symposium on Particulate Preparations and Design; Toyohashi, Japan, Oct. 24-25, 2001, p.154-165.
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H. Leuenberger, Scale-up in the field of Granulation and Drying. Chapter in Pharmaceutical Process Scale-Up, Vol.118, (2001): 151-170. ISBN 0-8247-0625-0. Marcel Dekker Inc., Editor: Michael Levin.
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H. Leuenberger, Scale-up in the 4th dimension in the field of granulation and drying. Preprint. 7th International Symposium on Agglomeration, Albi, France, June 29-31, 2001, p.375-384.
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A. Mann, M. Kiefer, and H. Leuenberger, Thermal Sterilization of Heat Sensitive Products using High-Temperature Short-Time Sterilization, J. Pharm. Sci. Vol.90 (3), (2001): 275-287.
- Annual Report 2001, Institute of Pharmaceutical Technology, University of Basel, (pdf)
Year: 2000
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KH. Leuenberger, Focus on research in nanoscience and nanotechnology in Switzerland, Journal of Nanoparticle Research Vol. 2, (2000): 391–392.
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M. Kuentz, H. Leuenberger, A new model for the hardness of a compacted particle system, applied to tablets of pharmaceutical polymers, Powder Technol. Vol. 111, (2000):145-153.
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M. Kuentz and H. Leuenberger, A new theoretical Approach to Tablet Strength of a Binary Mixture Consisting of a well and poorly compactable Substance, Eur.J. of Pharmaceutics and Biopharm. Vol.49, 2000): 151-159.
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K. Iida, H. Leuenberger, L-M. Fueg, R. Mueller-Walz, H. Okamoto, K. Danjo: Effect of Mixing of Fine Carrier Particles on Dry Powder Inhalation Property of Salbutamol Sulphate (SS), Journal of the Pharmaceutical Society of Japan (Japanese) Vol.120:(1), (2000):113-119.
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H. Leuenberger and S. Kocova El Arini, Solubilization Systems - The Impact of Percolation Theory and Fractal Geometry, Book Chapter in: Water-Insoluble Drug Form. (2000):569-607. Editor: Liu, Rong. Publisher: Interpharm Press
- Annual Report 2000, Institute of Pharmaceutical Technology, University of Basel, (pdf)
Year: 1999
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K. Iida, H. Leuenberger, L-M. Fueg, R; Müller-Walz, K. Danjo, Effect of Separation Characteristics between Slbutamol sulfate (SS) Particles and Model Carrier Excipients on Dry Powder for Inhalation (publication in Japanese), YaZa, Vol.119 (10),(1999): 752-762.
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M. Kuentz, H. Leuenberger, M. Kolb, Elasticity of polymer tablets considered as a network of contacts. S.T.P. Pharma Sci. Vol, 9 (6) (1999): 531-538.
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H. Leuenberger, The application of percolation theory in powder technology (Invited review), Advanced Powder Technology Vol. 10, (1999): 323-353.
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M. Kuentz, H. Leuenberger, Pressure susceptibility of polymer tablets as a critical property: A modified Heckel equation, J. Pharm. Sciences, Vol. 88, (1999):174-179.
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S .Amann, C. Reinke, G. Valet, U. Moser, H. Leuenberger, Flow-cytometric investigation of cellular metabolism during oxidative stress and the effect of tocopherol. Internat. J.Vit. Nutr.Res, 69:(5), 356-361 (1999).
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M. Kuentz, H. Leuenberger, M. Kolb, Fracture in disordered media and tensile strength of microcrystalline cellulose tablets at low relative densities, Int. J. of Pharmaceutics Vol. 182:(1999):243-255.
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C. Siegmund, H. Leuenberger, Percolation theory, conductivity and dissolution of hydrophilic suppository bases (PEG systems), International Journal of Pharmaceutics, Vol.189, (1999): 187-196.
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S. Kocova, H. Leuenberger, Dissolution Properties of Praziquantel - PVP Systems, Pharm. Acta Helv. 73 (2), (1998): 89-94.
Year: 1998
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J. Peters, G. Paulini, I. Conrot Bouley, G. Wolany, H. Leuenberger ,Validation of a Fully Automated Inspection Machine for the 100% Inline Control of Prefilled Syringes,Proceedings, 16th PDA International Congress; Basel February 23- February 25, 1998.
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H. Leuenberger, Order in Complex Pharmaceutical Systems of Disordered Media (Orden en sistemas farmacéuticos complejos formados por medios desordenados), Inaugural Lecture, Inauguration at the Royal Academy of Pharmacy of Spain, Madrid, March 5, 1998.
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B. Dörr and H. Leuenberger, Development of a new plant for quasi-continuous granulation and multiple chambered fluid-bed drying of pharmaceutical granules, Pre-prints of the 1st European Symposium: Process Technology in Pharmaceutical and Nutritional Sciences (Editor: H. Leuenberger, Basel), ISBN 3-921590-55-8, PARTEC 98, Nürnberg, March 10-12, 1998, p. 247-256.
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H. Leuenberger, Granulation - Novel Concepts. (in Japanese), 4th International Meeting on Chemical Engineering and Biotechnology; Beijing, Proceedings AchemAsia 1998, p.168-169.
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G. Imanidis, S. Helbing-Strausak, R. Imboden and H. Leuenberger. Vehicle-dependent In Situ Modification of Membrane-controlled Drug Release. J. Control. Release 51:23-34 (1998).
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H. Leuenberger, How to Monitor and Control the Moist Agglomeration Process, Book Chapter in „Data Acquisition and Measurement Techniques“, ed. Angel Muñoz-Ruiz. Interpharm Press Inc., Buffalo Grove, Illinois, ISBN 1-57491-037-X, p. 141-157, 1998.
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L.-M. Fueg, K. Iida, H. Leuenberger, R. Müller-Walz, Relationship between fine Particle Fraction and Percentage of Drug Retained after Air Jet Sieving of Model Carrier-Based Salbutamol Dry Powders for Inhalation, book chapter in Drug Delivery to the Lungs IX, The Aerosol Society, ISBN 0 9529777 02, Westminster, London, p. 64-67 (1998).
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M. Kuentz and H. Leuenberger, Modified Young's Modulus of Microcrystalline Cellulose Tablets and the Directed Continuum Percolation Model, Pharm. Development and Technology, Vol. 3:(1), (1998): 13-19.
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B. Lückel, D. Bodmer, B. Helk, H. Leuenberger, Formulations of Sugars with Amino Acids or Mannitol - Influence of Concentration Ratio on the Properties of the Freeze Concentrate and the Lyophilizate, Pharmaceutical Development and Technology, Vol. 3:(3), (1998): 325-336.
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S. Kocova El Arini and H. Leuenberger, Dissolution Properties of Praziquantel - PVP Systems Silvia Kocova El Arini and Hans Leuenberger Pharm. Acta Helv. 73: (1998): 89-94.
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S. Kocova, D. Giron and H. Leuenberger, Solubility Properties of Racemic Praziquantel and its Enantiomers, Pharm. Development and Technology, Vol. 3:(4), (1998): 557-564.
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G. Imanidis, S. Helbing-Strausak, R. Imboden, H. Leuenberger Vehicle-dependent in situ modification of membrane controlled drug release, J. of Controlled Release Vol. 51:(1998): 23-34.
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S. Kocova, D. Giron, H. Leuenberger, Solubility Properties of Racemic Praziquantel and its Enantiomers, Pharm. Dev. Technol. Vol. 3 (4), (1998): 557-564.
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J. Bourquin, H. Schmidli, P. van Hoogevest, H. Leuenberger, Comparison of artificial neural networks (ANN) with classical modeling techniques using different experimental designs and data from a galenical study on a solid dosage form, Eur. J. Pharm. Sci. Vol. 6 (4), (1998): 287-301.
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J. Bourquin, H. Schmidli, P, van Hoogevest, H. Leuenberger, Advantages of Artificial Neural Networks (ANNs) as alternative modeling technique for data sets showing non-linear relationships using data from a galenical study on a solid dosage form. Eur. J. Pharm. Sci. Vol. 7 (1), (1998): 5-16.
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J. Bourquin, H. Schmidli, P. van Hoogevest, H. Leuenberger Pitfalls of artificial neural networks (ANN) modeling technique for data sets containing outlier measurements using a study on mixture properties of a direct compressed dosage form, Eur. J .Pharm. Sci. Vol.7 (1), (1998): 17-28.
Year: 1997
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J .Bourquin, H. Schmidlin, P .van Hoogevest and H. Leuenberger, Basic Concepts of Artificial Neural Networks (ANN) Modelling in the Application to Pharmaceutical Development, J. Pharm. Development and Technology Vol. 2, (1997):95-109.
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J. Bourquin, H. Schmidlin, P. van Hoogevest and H. Leuenberger Application of Artificial Neural Networks (ANN) in the Development of Solid Dosage Forms ,J. Pharmaceutical Development and Technology, Vol.2:(2), (1997): 111-121.
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L. Frederiksen, K. Anton, P. van Hoogevest, H. R. Keller and H. Leuenberger, List of Preparation of Liposomes Encapsulating Water Soluble Compounds Using Supercritical Carbon Dioxide, J. Pharm. Sci. Vol. 86,(1997): 921 –928.
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G. Imanidis, F. Rosa, H. Leuenberger, Permeation of a probe molecule (mannitol) through phospholipid bilayer membranes: correlation with membrane microviscosity. Proceedings of the 24th International Symposium on Controlled Release of Bioactive Materials; Stockholm 1997, ISSN 1022-0178.
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G. Imanidis, P. Lütolf, H. Leuenberger, An extended model based on the modified Nernst-Planck equation to describe transdermal iontophoresis of amphoteric compounds, Proceedings of the 24th International Symposium on Controlled Release of Bioactive Materials; Stockholm 1997, ISSN 1022-0178.
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P. Lütolf, G. Imanidis and H. Leuenberger. Transdermal Iontophoresis of an Amphoteric Compound: Effect of Charge and Interaction with Human Skin, In: P.Couvreur, D.Duchéne, P.Green and H.E.Junginger (Eds.), Transdermal Administration, A Case Study, Iontophoresis, Editions de Santé, Paris, 1997, pp. 360-364.
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M. Madörin, P. van Hoogevest, R. Hilfiker, B. Langwost, G.M.Kresbach, M. Ehrat, H. Leuenberger, Analysis of drug/plasma protein interactions by means of asymmetrical flow field-flow fractionation Pharm. Res. Vol. 14 (12), (1997):1706-1712.
H. Leuenberger and L. Ineichen, Percolation theory and physics of compression, European Journal of Pharmaceutics and Biopharmaceutics Vol. 44, (1997): 269-272. -
H. Leuenberger, Pharmaceutical technology and quality assurance: the impact of novel concepts in the production of granules and tablets, S.T.P.Pharma Sci. Vol. 7 (1), (1997): 19-25.
Year: 1996
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G. Imanidis, C. Waldner, C. Mettler and H. Leuenberger. An Improved Diffusion Cell Design for Determining Drug Transport Parameters across Cultured Cell Monolayers. J. Pharm. Sci. 85:1196-1203 (1996).
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H. Leuenberger ,Percolation Theory and Robust Formulations in Powder Technology, in Proceedings '96 China-Japan Symposium on Particuology edited by Yong Jin, Mooson Kwauk, Genji Jimbo and Yasuo Konseka, Tsinghua University Beijing May 24-25, 1996.
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Bernhard G. Müller, Hans Leuenberger and Thomas Kissel, Albumin Nanospheres as Carriers for Passive Drug Targeting: An Optimized Manufacturing Technique, Pharm. Res. Vol. 13:(1), (1996): 32-37.
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H. Leuenberger, Application of Percolation Theory in the Field of Powder Technology, publication No.95d, Proceedings of the 2nd International Particle Technology Forum; San Diego 14.07.96 - 18.07.96 in conjunction with 5th World Congress of Chemical Engineering.
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I. Caraballo, M. Millan, A. Rabasco, and H. Leuenberger, Zero-order release periods in inert matrices. Influence of the distance to the percolation threshold, Pharm. Acta Helv. Vol. 71:(5) (1996): 335-339.
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H. Leuenberger , Percolation Theory and Robust Formulations in Powder Technology, Proceedings '96 China-Japanese Symposium on Particuology ,May 24/25 1996, Beijing, edited by Yong Jin, Mooson Kwauk, Genji Jimbo, Yasuo Kousaka, p. 37-41.
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S. Kocova El Arini and H. Leuenberger, Dissolution properties of praziquantel-β-cyclodextrin systems, Pharmaceutical Development and Technology, Vol. 1:(3), (1996): 307-315.
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I. Caraballo, M. Fernández-Arévolo, M. Millán, A. M. Rabasco, H. Leuenberger, Study of percolation thresholds in ternary tablets. International Journal of Pharmaceutics Vol. 139, (1996): 177-186.
Year: 1995
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LH. Leuenberger, J. D. Bonny, M. Kolb, Percolation Effects in Matrix-Type Controlled Drug Release Systems, Int. J. of Pharm. Vol.115:(1995): 217-24.
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S. Kocova El Arini and H. Leuenberger, Modeling of drug release from polymer matrices: Effect of drug loading, Int. J. of Pharm. Vol.121, (1995): 141-148.
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H. Leuenberger, S Kocova El Arini, Solubilization Systems – The Impact of Percolation Theory and Fractal Geometry, book chapter,in Water Insoluble Drug Formulation, Editor Rong Liu, Interpharm Press, Denver, Colorado, p.569-590.
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P. Schlagenhauf, R. Steffen, A. Tschopp, P. Van Damme, M.-L.Mittelholzer, H. Leuenberger & C. Reinke, Behavioral aspects of travelers in their use of malaria presumptive treatment Bulletin of the World Health Organization, Vol. 73:(2), (1995):1-7.
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H. Leuenberger, Pharmaceutical technology and quality assurance: the impact of novel concepts in the production of granules and tablets, International Meeting on Chemical Engineering and Biotechnology, Proceedings ACHEMASIA '95, 16/5/95, Peking, China.
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L. Savastano, H. Leuenberger, H. P. Merkle, Membrane modulated dissolution of oral drug delivery systems, Pharm. Acta Helv., Vol.70, (1995): 117-124.
Year: 1994
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R. Luginbühl and H. Leuenberger, Use of Percolation Theory to Interpret Water Uptake, Disintegration Time and Intrinsic Dissolution Rate of Tablets Consisting of Binary Mixtures, Pharm. Acta Helv. Vol. 69:(1994): 127-134.
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R. Randegger, G. Imanidis, R .D .Juch, G .Birrenbach, H.Leuenberger Prozess Monitoring bei der Emulsionsherstellung Drehmomentenmessung als In Prozess Kontrolle bei der Emulsionsherstellung, Pharm. Ind. Vol. 56:(1994): 648-654.
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A. Bausch and H. Leuenberger ,Wet spherical agglomeration of proteins as a new method to prepare parenteral fast soluble dosage forms, Int. J. of Pharm. Vol. 101:(1994): 63-70.
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I. Caraballo, M. Fernandez-Arevalo a, M.A. Holgado, A.M. Rabasco, H. Leuenberger, Study of the release mechanism of carteolol inert matrix tablets on the basis of percolation theory, Int. J. Pharm. Vol. 109, (1994): 229-236.
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R. Luginbuehl, H. Leuenberger, Use of percolation theory to interpret water uptake, disintegration time and intrinsic dissolution rate of tablets consisting of binary mixtures, Pharm. Acta Helv. Vol. 69 (1994): 127-134.
Year: 1993
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H. Leuenberger, Size Enlargement of Pharmaceutical Powders & Wet Agglomeration and Drying Techniques, Invited Review, Kona Nr 11, (1993): 69-78.
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J. D. Bonny and H. Leuenberger, Matrix-Type Controlled Release Systems: I. Effect of Percolation on Drug Dissolution Kinetics, Pharm. Acta Helv. 68:(1993): 25-33.
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H. Leuenberger, Design and Optimization Approaches in the Field of Granulation, Drying and Coating, Pharmacy World Congress '93, Tokyo, Proceed. of the 53rd Int. Congress of Pharm. Sciences 1993, D. J. S. Crommelin, K. K. Midha, T. Nagai editors, Medpharm. Scientific Publishers, Stuttgart 1994, p. 493-511.
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R. Leu, and H. Leuenberger, The application of Percolation Theory to the Compaction of Pharmaceutical Powders, Int. J. Pharm. Vol. 90, (1993) : 213-219.
Year: 1992
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H. Leuenberger and R. Leu, Formation of a Tablet: A Site-Bond Percolation Phenomenon, J. Pharm. Sci. Vol.81, 10, (1992): 976-982.
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A. Schade, H. Leuenberger, Herstellung pharmazeutischer Granulate in einem kontinuierlichen Feuchtagglomerations – und Mehrkammer Wirbelschichttrocknungs-Verfahren, Chem. Ing. Tech. Vol. 64 (1992): 1016-1018.
Year: 1991
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M. Mumenthaler and H. Leuenberger, Atmospheric Spry Freeze Drying: a suitable alternative in freeze drying technology, Int. Journal of Pharm. Vol. 72, (1991): 97-110.
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J.D. Bonny and H. Leuenberger, Matrix type controlled release systems I: Effect of Percolation on Drug Dissolution Kinetics, Pharm. Acta Helv. Vol. 66, 5-6, (1991): 160-164.
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L.E. Holman and H. Leuenberger, The significance of slopes of the semi-logarithmic relationship between hardness and the solid fraction of porous compacts, Powder Tech. Vol.64, (1991): 233-247.
Year: 1990
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M. Usteri, J.D. Bonny and H. Leuenberger, Fractal Dimension of Porous Solid Dosage Forms, Pharm.Acta Helv. Vol. 65:Nr. 2 (1990): 55-61.
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H. Leuenberger, Design and Modification of Powders - A Must in Pharm. Technology, Proceed. 2nd World Congress Particle Technology, Sept. 19-22, 1990, Kyoto, Japan Vol. III. p. 317-328.
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L.E. Holman and H. Leuenberger, The Effect of Varying Composition of Binary Powder Mixtures and Compacts on their Properties, Powder Tech. Vol.60, 249-258.
Year: 1989
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H. Leuenberger, L. Holman, M. Usteri and S. Winzap, Percolation Theory, Fractal Geometry and Dosage Form Design, Pharm.Acta Helvetiae Vol. 64, (1989):34-39.
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H. Leuenberger, M. Usteri, G. Imanidis and S. Winzap Monitoring the Granulation Process: Granulate Growth, Fractal Dimensionality and Percolation Threshold, Boll. Chim. Pharm. Vol. 128:(1989): 54-61.
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B. Luy, B. Hirschfeld and H. Leuenberger, Granulation and Drying in Vacuum Fluidised Bed Systems, Drugs made in Germany Vol.32, (1989):3-8.
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M. Usteri and H. Leuenberger Agglomeration of Binary Mixtures in a High-Speed Mixer, Int.J.of Pharm. 55:(1989): 135-141.
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L.E. Holman, H. Leuenberger, Effect of Compression Speed on the relationship between normalized solid fraction and mechanical properties of compacts, Int. J. Vol. 57, (1989): R1-R5.
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H. Leuenberger, J.D. Bonny, C.F. Lerk, and H. Vromans, Relation between crushing strength and internal specific surface area of lactose compacts, Int. J. Pharm. Vol.52, (1989): 91-100.
Year: 1988
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L.E. Holman and H. Leuenberger, The relationship between solid fraction and mechanical properties of compacts – the percolation theory model approach, Int. J. Pharm. Vol.46, (1988) : 35- 44.
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B. Lückel, B. Helk, D. Bodmer, H. Leuenberger Effects of Formulation and Process Variables on the Aggregation of Freeze-Dried Interleukin-6 (IL-6) After Lyophilization and on Storage, Pharmaceutical Development and Technology, Vol.3:(3), (1988): 337-346.
Year: 1987
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H. Leuenberger, B. D. Rohera and C. Haas, Percolation Theory A Novel Approach to Solid Dosage Form Design, Int. J. Pharm., Vol. 38 (1987): 109115.
Year: 1986
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H. Leuenberger, Statistische Mehoden zur Planung und Auswertung, book chapter in Pharmazeutische Technologie, editors: K. H. Bauer, K. H. Froemming, C.Fuehrer, 1986, 1st edition, Thieme Verlag, Stuttgart, 2nd edition 1989.
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H. Leuenberger and G. Imanidis, Monitoring Mass Transfer Processes in order to control moist agglomeration, Pharm. Techn. Vol. 10 (1986): 56 – 73.
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H. Leuenberger and B. D. Rohera, Fundamentals of Powder Compression. I. The Compactibility and Compressibility of Pharmaceutical Powders, Pharmaceutical Research, Vol. 3(1), (1986): 1222.
- H. Leuenberger and B. D. Rohera, Fundamentals of Powder Compression. II. The Compression of Binary Powder Mixtures, Pharmaceutical Research, Vol. 3(2), (1986): 6574.
Year: 1985
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B. D. Rohera, W. Jetzer and H. Leuenberger, Compression Study of Binary Powder Mixtures consisting of Brittle and Plastic Substances, Proceedings of the 4th International Symposium on Agglomeration, Toronto, Canada, June (1985): 571577.
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W. Jetzer, H. Leuenberger, Ueber das Komprimierverhalten von NaCl, KCl und Hexamethylentetramin, Powder Tech., Vol.42, (1985): 137-144.
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H. Leuenberger, Compression of binary powder mixtures and solubility parameters of solids, Int. J. of Pharm. Vol. 27, (1985): 127- 138.
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H. Leuenberger, Agglomeration ’85, 4th International Symposium on Agglomeration (Co-sponsor: Iron & Steel Society), Toronto, Canada, and report on his lecture regarding the Intensive Course on Fundamentals on Agglomeration together with Prof. R. Batterham (CSIRO, Australia), Dr. C. E. Capes (National Research Council of Canada), Prof. P.F. Wynnyckyj at Waterloo University, Waterloo, etc. SWISS PHARMA, Vol.7, 7-8 (1985): 13-17.
Year: 1984
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W. Jetzer, H. Leuenberger, Zur Bestimmung der Deckeltendenz von pharmazeutischen Wirk- und Hilfsstoffen, Pharm. Acta Helv. Vol.59, 1, (1984): 2-7.
Year: 1983
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H. Leuenberger, Scale-up of Granulation Processes with -Reference to Process Monitoring, Acta Pharm. Techn. 2:(1983): 274-280.
Year: 1982
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H. Leuenberger, Granulation - New Techniques, Pharm. Acta Helv. Vo.57, 3 (1982): 72-82.
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H. Leuenberger, Compressibility and Compactibility of powder systems, Int. J. of Pharm. Vol.12, (1982): 41-55.
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M. Duerrenberger & H. Leuenberger, Steuerung und Ueberwachung konventioneller Granulierprozesse, Chem. Rundschau (1982); 1-3.
Year: 1981
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H. Leuenberger, E.N. Hiestand, & H. Sucker, Ein Beitrag zur Theorie der Pulverkompression, Chemie - Ing. Tech., Vol.53, 1, (1981): 45-47.
Year: 1980
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H. Leuenberger, GSIA Kurs 1979/80, Ausgewaehlte Grundlagen Pharmazeutischer Technologie, das Verpressen von pulverfoermigen Haufwerken, 7.2.1980, p.1 –p.49.
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H. Leuenberger, Zur Theorie der Pulverkompression, Habilitation Thesis, Faculty of Science, University of Basel, p.1 –p.93 (1980).
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P.F. Ni, N.F.H. Ho, J.L. Fox, H. Leuenberger & W.I. Higuchi, Theoretical Model Studies of Intestinal Drug Absorption V. Non-steady Fluid Flow and Absorption, Int. J. of Pharm., Vol. 5, (1980): 33-47.
Year: 1979
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H. Leuenberger, H. P. Bier and H. Sucker, Theory of the Granulating Liquid Requirement in the Conventional Granulation Process, Pharm. Techn. Intern. Vol. 3:(1979): 60-67.
Year: 1978
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H. Leuenberger, chapter, Einfuehrung in die mathematischen Grunndbegriffe in Pharmazeutische Technologie, editors: H. Sucker, P. Fuchs, and P. Speiser, Georg Thieme Verlag, Stuttgart, 198 p.1-p.92.
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P. Guitard, H. Leuenberger, H. Sucker, Optimisation Statistique d’ une Formulation Pharmaceutique, Labo Pharma, Problemes et Techniques, Vol.280, (1978): 827-857.
Year: 1977
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H. Leuenberger, GSIA Fortbildungskurs 1976/77 Datenverarbeitung und Interpretation in der Pharm. Praxis: Vergleich zwischen klassischer und statistischer Versuchsplanung vom 3.2. 1977, p.1-p.16.
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R. Gurny, P. Burri, H. Sucker, P. Guitard and H. Leuenberger, Etude par analyse orthogonale des facteurs influencant le transport a travers un film plan, Pharm Acta Helv. Vol. 52, 8, (1977): 175-187.
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R. Gurny, P. Burri, H. Sucker, P. Guitard and H. Leuenberger, Etude par regression lineaire multiple des facteurs technologiques influencant laliberation d’un principe actif a partir des microgranules enrobes par fluidization, Pharm. Acta Helv., Vol. 52, 10, (1977): 247-251.
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H. Leuenberger, and P. Guitard, Delivery Systems for Patient Compliance, Presentation at the World congress in Brussels, p.358-371, 1977.
Year: 1976
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H. Leuenberger, P. Guitard und H. Sucker, Mathematische Modellierung und Optimierung pharmazeutisch-technologischer Qualitätsmerkmale fester Arzneiformen, Pharmazie in unserer Zeit Vol. 5: (1976):65-76.
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H. Leuenberger und Y. Zimmermann, Eine Versuchsanordnung zur Messung der elektrostatischen Aufladung von Granulaten, Pharm. Ind. Vol.38,9, (1976): 832-836.
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H. Leuenberger und Y. Zimmermann, Elektrostatische Aufladung von Granulaten und freifliessenden Pulvern, Acta Pharm. Tech. Vol. 22, 4, (1976): 255-266.
Year: 1975
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H. Leuenberger and W. Becher, A Factorial Design for Compatibility Studies in Preformulation Work, Pharm.Acta Helv. Vol. 50, (1975): 88-91.
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P. Guitard, H. Leuenberger und H. Sucker, Maximal zulaessige Partikelgroesse von Hilfsstoffen in Mischungen fuer feste Arzneiformen, Pharm. Ind. Vol. 37, 5, (197): 357-360.
Nuclear Science
Year: 2024
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A. M. Comunetti (ⴕ), and H. Leuenberger, Lockage of the First Excited Stage of 198Hg. Vol.11, sips23_65_333FS, Proceedings of 2023 Sustainable Industrial Processing Summit, edited by F. Kongoli, F. Murad, T. Yoshikawa, J.R. Ribas, D. Joseph, N. Tran, S. Hirano FLOGEN 2023.
Year: 2023
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A. M. Comunetti (ⴕ), and H. Leuenberger, Blockage of the First Excited Stage of 198Hg, SIPS Summit, November 27- December 1, 2023, at Hyatt Playa Bonita, Panama City ppt presentation, pdf version can be downloaded from https://www.ifiip.ch. This presentation on the topic of nuclear science describes a method to reverse the original (n,) process of a nuclear power plant leading to radioactive waste. Thus, this ( n) process avoids burying the radioactive waste in a safe place since the resulting nuclei are no longer radioactive.
Year: 1973
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H. Leuenberger, Interpretation of the Change in Half-Life of 89Zr in BaTi(Zr)O3 at the upper Phase Transition, Physica (1973): 621-624.
Year: 1972
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H. Leuenberger, P. Huber (ⴕ), P. Nyikos, H.R. Kobel, and H. Seiler, Effect of an External Electric Field on the Decay Constant of 99Tcm in Halogen Complexes, Helvetica Chimica Acta, Vol. 55, (1972): 961-969.
Year: 1971
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H. Leuenberger, PhD thesis in Nuclear Physics under the guidance of Prof. Paul Huber with the German title Veraenderung der Halbwertszeit von 99Tcm in verschiedenen chemischen Komplexen durch ein aeusseres elektrisches Feld (Effect of an External Electric Field on the Decay Constant of 99Tcm Halogen Complexes), Faculty of Science, University of Basel.
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P. Nyikos, H.P. Bier, P. Huber, H.R. Kobel, H. Leuenberger, and H. Seiler, Aenderung der Zerfallskonstante von 198Au in verschiedenen chemischen Umgebungen.
Year: 1970
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S. Gagneux, P. Huber, H. Leuenberger & P. Nyikos, Aenderung der Zerfallskonstanten von 89Zr in BaTiO3, Helv. Phys. Acta, Vol. 43, 5, (1970): 39-58.
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H. Leuenberger, S. Gagneux, P. Huber, H.R. Kobel, P. Nyikos & H. Seiler,S., Abstract (1 page) Beeinflussung der Halbwertszeitszeit von 99Tcm durch ein aeusseres elektrisches Feld, Helv. Phys. Acta, Vol. 43, 5, (1970): 60.
Year: 1968
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P. Huber, S. Gagneux, H. Leuenberger, Influence of the Internal Electric Field in BaTiO3 on the lifetime of 89Zr. Physics Letters Vol. 27B, 2 (1968): 86-87.
Year: 1967
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H. Leuenberger, Master thesis (in Nuclear Science) with the title in English «Intensity measurements at the source of polarized deuterons», Institute of Experimental Physics, University of Basel, Switzerland.